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What is Trofile™

Trofile Educational Video:

English version
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Trofile is a state-of-the-art complex molecular assay that identifies the tropism of a patient's HIV

 

Trofile DNA
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Trofile
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Over 23,000 samples have been tested using this assay and Trofile™ is regarded as the gold standard in tropism testing.

All trials of co-receptor antagonists have used Trofile in the clinical development.

Trofile has been shown to be accurate, precise, sensitive, reproducible and robust in the measurement of HIV-1 co-receptor tropism.

Announcing a new benchmark for HIV tropism identification13

  • 100% Sensitive at detecting 0.3% CXR4-using minor variant 19
  • Uses the complete gp160 coding region of the HIV-1 envelope protein to ensure that all determinants of tropism are tested 19
  • Successful amplification and reliable results with viral load ≥1,000 copies/mL

Know your patient's Tropotype™ before prescribing a CCR5 antagonist

  • Trofile identifies the tropism of an individual patient's HIV strain – R5, X4, or a combination of these known as dual/mixed (D/M)13
  • Identifying tropism is important for completing your patient's HIV profile


How does Trofile™ work?

Trofile is a single-cycle recombinant virus assay in which a pseudovirus is generated from full length envelope (env) genes derived from the patient’s virus population. The complete envelope is used to determine viral tropism taking into account determinants that lie outside the V3 loop.